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在我们过去的研究中,发现全身性红斑狼疮(SLE)病人补体第一途径成分C4基因的不表达情况(QO)频率特高,而补体第二途径B因子(Bf)的快带别型(F)频率也高,那末这两者之间有否联系呢?因此用我室已建立的C4及Bf别型检测方法对58例SLE病人C4QO数目与Bf别型之间的相关性进行了检测,并与130例正常人作了对照,结果如表1。现确知,C4有两个基因座位,分别命名为C4A~*与C4B~*,它们都可以同合子方式不表达,所以最多可以有四个QO。这种C4两个基
In our previous studies, we found that patients with systemic lupus erythematosus (SLE) had a particularly high frequency of C4 expression of the first pathway of complement (QO), whereas fast complement allele (Bf) of the second pathway complement factor B (Bf) F) the frequency is high, then there is a relationship between the two? Therefore, with our established C4 and Bf non-specific detection of 58 patients with SLE patients C4QO number and Bf-type correlation was detected between , And compared with 130 normal people, the results shown in Table 1. Now we know that C4 has two loci, named as C4A ~ * and C4B ~ *, all of which can not be expressed in the same way as homozygotes, so there can be up to four QOs. This C4 two bases