论文部分内容阅读
background Studies showed that arterial elasticity changes appear earlier than any structural changes, therefore, its accurate evaluation could be applied at early stage to prevent disease. Echo-tracking(E-tracking) technique can track the wall motion trajectory in real-time, calculate the change in vascular diameter automatically, and assessment of vascular stiffness and flexibility directly. This article aims to assess the change of elasticity of carotid artery after hormone therapy (HT) using Echo-tracking technology. Methods Echo-tracking was used to evaluate the carotid elastic moduli, such as the pressure-strain elastic modulus (Eρ), stiffness parameter (β), arterial compliance (AC), pulse wave conducting velocity (PWVβ) and augmentation index (AI) by Aloka α10 color Doppler ultrasound diagnosis system. Results Eρ, β and PWVβ in HT group were significantly lower than those in the control group (P < 0.01), while AC was obviously higher than the control group (P < 0.01). E2 was negatively related to β, Eρ and PWVβ (r = -0.607, r = -0.573, r = -0.574, P < 0.001), while positively related to AC (r = 0.574, P < 0.001); endothelial-dependent dilatation (EDD) was negatively related to β, Eρ and PWVβ (r = -0.521, r = -0.411, r = -0.456, P < 0.001), while positively related to AC (r = 0.443, P < 0.001); But IMT was positively related to β, Eρ and PWVβ (r = 0.553, r = 0.444, r = 0.529, P < 0.001), while negatively related to AC (r = -0.400, P < 0.001). Conclusions Arterial stiffness increases and compliance decreases in menopausal women. As EDD decreases arterial elasticity recedes, and HT can improve arterial elasticity. E-tracking technology can discover the early changes in arterial stiffness effectively and it is more sensitive in finding out the changes of stiffness in early atherosclerosis than IMT of carotid artery.
background studies showed that arterial elasticity changes appear earlier than any structural changes, therefore, its accurate evaluation could be applied at early stages to prevent disease. the change in vascular diameter automatically, and assessment of vascular stiffness and flexibility directly. This article aims to assess the change of elasticity of carotid artery after hormone therapy (HT) using Echo-tracking technology. Methods Echo-tracking was used to evaluate the carotid elastic moduli, such as the pressure-strain elastic modulus (Eρ), stiffness parameter (β), arterial compliance (AC), pulse wave conducting velocity (PWVβ) and augmentation index (AI) by Aloka α10 color Doppler ultrasound diagnosis system. Eρ, β and PWVβ in HT groups were significantly lower than those in the control group (P <0.01), while AC was significantly higher than the control group (P <0.01). E2 was negatively related to β, Eρ and PWVβ (r = -0.607, r = -0.573, r = -0.574, P <0.001) EDD) was negatively related to β, Eρ and PWVβ (r = -0.521, r = -0.411, r = -0.456, P <0.001) positively correlated to β, Eρ and PWVβ (r = 0.553, r = 0.444, r = 0.529, P <0.001), while negatively related to AC E-tracking technology can discover the early changes in arterial stiffness effectively and it is more sensitive in finding out the changes of stiffness in early atherosclerosis than IMT of carotid artery .