论文部分内容阅读
自由基参与许多病理过程,它对生物体的主要损伤是脂质过氧化作用。地中海贫血(简称地贫)患者由于珠蛋白肽链合成部分或全部受到抑制,以致红细胞内有相对过剩的α或β肽链,较正常血红蛋白 A 更易发生自氧化,释放大量 O(?),使红细胞膜上的多不饱和脂肪酸受过氧化损伤,产生多量丙二醛(MDA),进一步损伤红细胞膜及血红蛋白,致使地贫红细胞膜的流动性和变形性下降,使红细胞形态及功能改变,导致红细胞寿命缩短,发生慢性溶血。
Free radicals participate in many pathological processes, and its main damage to the organism is lipid peroxidation. Thalassemia (thalassemia) patients due to globin peptide synthesis part or all of the inhibition, resulting in a relative excess of red blood cells in the α or β peptide chain, compared with normal hemoglobin A more prone to autoxidation, release a large number of O (?), So that Polyunsaturated fatty acids on the erythrocyte membrane are oxidatively damaged, resulting in a large amount of malondialdehyde (MDA), which further damages the erythrocyte membrane and hemoglobin, resulting in a decrease in fluidity and deformability of the thalamic erythrocyte membrane, which changes the morphology and function of erythrocytes, Shortened life expectancy, chronic hemolysis occurs.