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【目的】探讨HBsAg阳性孕妇的新生儿乙肝联合免疫前的HBV-M和HBV DNA预测HBV宫内感染的实用价值。【方法】对我院2006年6月至2008年2月间分娩的HBsAg阳性孕妇的420例婴儿,其中新生儿HBsAg或HBV DNA阳性为33例,HBsAg和HBV DNA双阳性共6例,对其满6月龄时进行随访,复查HBV-M以确诊HBV宫内感染。【结果】HBV宫内感染率为0.95%(4/420),新生儿HBsAg或HBV DNA阳性诊断HBV宫内感染的阳性似然比为14.3,而HBsAg和HBV DNA双阳性时诊断宫内感染的阳性似然比为208.3。【结论】HBsAg阳性孕妇的新生儿乙肝联合免疫前的HBsAg和HBV DNA双阳性对HBV宫内感染具有较准确的预测作用,可以作为HBV宫内感染的初步临床诊断。
【Objective】 To explore the practical value of HBV-M and HBV DNA in predicting HBV intrauterine infection in neonates with HBsAg positive pregnant women before combined immunization. 【Methods】 A total of 420 HBsAg-positive pregnant women who gave birth between June 2006 and February 2008 in our hospital were enrolled. Among them, 33 were HBsAg or HBV DNA positive in newborns, 6 were double positive for HBsAg and HBV DNA, Full 6-month-old follow-up, review of HBV-M to confirm HBV intrauterine infection. 【Results】 The intrauterine infection rate of HBV was 0.95% (4/420). The positive likelihood ratio of neonatal HBsAg or HBV DNA positive diagnosis of HBV intrauterine infection was 14.3, while the intrauterine infection was diagnosed by double positive of HBsAg and HBV DNA The positive likelihood ratio is 208.3. 【Conclusion】 The double positive of HBsAg and HBV DNA before HBsAg positive pregnant women with HBsAg positive pregnant women have a more accurate prediction of HBV intrauterine infection, which can be used as a preliminary clinical diagnosis of HBV intrauterine infection.