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目的:探讨通络益智汤联合西药对缺血性脑白质疏松症患者临床检验指标及凝血功能的影响。方法:通过对我院2014年7月~2016年7月神经内科就诊收治的240例缺血性LA患者临床资料做回顾性分析。并根据治疗方式的不同分为观察组、对照组(各120例)。比较并分析两组患者治疗前后的认知功能评分、血液流变学指标及主要的凝血指标等。结果:两组患者治疗前认知功能评分比较,差异无统计学意义(P>0.05),治疗后两组患者认知功能评分均较治疗前高,差异具有统计学意义(P<0.05),且观察组认知功能评分较对照组改善明显,差异具有统计学意义(P<0.05)。两组患者治疗前血液流变学指标比较,差异无统计学意义(P>0.05),治疗后两组患者血液流变学指标均较治疗前整体改善,差异具有统计学意义(P<0.05),且观察组血液流变学指标较对照组改善明显,差异具有统计学意义(P<0.05)。两组患者治疗前各凝血指标比较,差异无统计学意义(P>0.05),其中PLT、D-D、APTT两组患者与治疗前比较有明显差异(P<0.05),且观察组均优于对照组(P<0.05),PT,TT两组患者比较无明显差异(P>0.05),且均较治疗前无明显差异(P>0.05)。结论:通络益智汤联合西药应用缺血性脑白质疏松症患者中,可有效改善其认知障碍,同时可对患者的凝血功能及血流动力学有所改善,进而可起到缓解供血不足的作用,值得临床推广。
Objective: To investigate the effect of Tongluo Yizhi decoction combined with western medicine on clinical test indexes and coagulation function in patients with ischemic leukoaraiosis. Methods: The clinical data of 240 patients with ischemic LA admitted to Department of Neurology in our hospital from July 2014 to July 2016 were analyzed retrospectively. According to the different treatment methods, the patients were divided into observation group and control group (120 cases each). Compare and analyze the cognitive function scores, hemorheology indexes and major coagulation indexes of the two groups before and after treatment. Results: There was no significant difference in cognitive function score between the two groups before treatment (P> 0.05). After treatment, the scores of cognitive function in both groups were significantly higher than those before treatment (P <0.05) The score of cognitive function in the observation group was significantly improved compared with the control group (P <0.05). There was no significant difference in hemorrheological parameters between the two groups before treatment (P> 0.05). After treatment, the hemorrheological indexes of the two groups were improved as compared with before treatment, the difference was statistically significant (P <0.05) , And the indexes of hemorheology in the observation group improved obviously compared with the control group, the difference was statistically significant (P <0.05). There was no significant difference in coagulation index between the two groups before treatment (P> 0.05). The PLT, DD and APTT groups were significantly different from those before treatment (P <0.05), and the observation group were better than the control group (P <0.05). There was no significant difference between PT and TT groups (P> 0.05), and there was no significant difference between the two groups before treatment (P> 0.05). Conclusion: Tongluo Yizhi Decoction combined with Western medicine in patients with ischemic leukoaraiosis can effectively improve the cognitive impairment, at the same time, it can improve the coagulation function and hemodynamics of the patients, and then can relieve the blood supply Insufficient role, it is worth clinical promotion.