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N-乙酰普鲁卡因酰胺(NAPA)是普鲁卡因酰胺的主要代谢产物,具有抗心律失常作用,但极少引起红斑狼疮样综合征。其电生理特性不同于普鲁卡因酰胺之处在于仅延长心脏复极化,对去极化几无作用。其对人血流动力学变量和心室功能的作用尚不清楚。方法:14例患者行诊断性心导管检查,平均年龄59(34～67)岁。单支、双支和三支心外膜冠脉(直径)狭窄≥50％者分别为4例、5例和2例。5例有陈旧性下壁心肌梗塞的病史或心电图证据。全组左室喷血分数(LVEF)为66±10％。检查前夜禁食,停用抗心律失常药、β-阻滞剂、钙拮抗剂和长效硝酸酯制剂至少48小时。经心导管测量右房压
N-acetyl-procaine amide (NAPA) is the main metabolite of procainamide, with anti-arrhythmic effects, but rarely cause lupus-like syndrome. Its electrophysiological properties are different from procainamide in that it only prolongs cardiac repolarization and has no effect on depolarization. Its effect on human hemodynamic variables and ventricular function is not clear. Methods: Fourteen patients underwent diagnostic cardiac catheterization, with an average age of 59 (34-67) years. Single, double and three epicardial coronary artery (diameter) stenosis ≥ 50% were 4 cases, 5 cases and 2 cases. Five patients had a history of inferior wall myocardial infarction or ECG evidence. The whole group left ventricular ejection fraction (LVEF) was 66 ± 10%. Check overnight fasting, anti-arrhythmic drugs, beta-blockers, calcium antagonists and long-acting nitrate formulations for at least 48 hours. Transcatheter catheterization of right atrial pressure