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子痫是一种孕期常见的危及生命的急性并发症,典型症状包括妊娠相关高血压和蛋白尿。子痫所致孕产妇死亡数占亚非地区孕产妇死亡的9%,在拉丁美洲及加勒比地区这一比例可上升至25%。包括免疫损伤、胎盘缺血和凝血激活在内的多种机制参与子痫的发生过程。本文根据目前所掌握国内外研究资料,对子痫前期及子痫的发病机制研究进展作一综述。
Eclampsia is a common and life-threatening acute complication during pregnancy. Typical symptoms include pregnancy-related hypertension and proteinuria. The number of maternal deaths caused by eclampsia accounts for 9% of maternal deaths in Asia and Africa, with the proportion rising to 25% in Latin America and the Caribbean. A variety of mechanisms, including immune damage, placental ischemia and coagulation activation, are involved in the development of eclampsia. This review summarizes the research progress on the pathogenesis of preeclampsia and eclampsia according to the current research data at home and abroad.