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目的观察丙戊酸钠对自发性蛛网膜下腔出血后癫痫发作的预防效果。方法选取自发性蛛网膜下腔出血患者52例,采用随机数字表法分为观察组和对照组各26例。观察组入院后给予丙戊酸钠预防,对照组入院时癫痫未发作前不使用任何抗癫痫药物,癫痫发作时给予丙戊酸钠治疗。对比2组患者癫痫发生情况及并发症发生情况。结果观察组患者癫痫发作率为15.38%明显低于对照组的34.62%,差异有统计学意义(P<0.05);2组患者胃肠道反应、嗜睡的发生率及并发症总发生率比较差异无统计学意义(P>0.05)。结论丙戊酸钠对自发性蛛网膜下腔出血后癫痫的发作具有良好的预防效果,且并发症发生率低,值得临床推广应用。
Objective To observe the preventive effect of sodium valproate on epileptic seizures after spontaneous subarachnoid hemorrhage. Methods Fifty-two patients with spontaneous subarachnoid hemorrhage were selected and randomly divided into observation group and control group with 26 cases in each group. The observation group was given prophylactic sodium valproate after admission, while the control group did not use any antiepileptic drugs before epilepsy was admitted before admission. The patients were given sodium valproate during seizure. Comparing two groups of patients with epilepsy and complications occurred. Results The incidence of epileptic seizures in observation group was significantly lower than that in control group (15.38% vs 34.62%, P <0.05). The incidences of gastrointestinal reactions, lethargy and total complication rates in two groups were significantly different No statistical significance (P> 0.05). Conclusion Sodium valproate has a good preventive effect on the onset of epilepsy after spontaneous subarachnoid hemorrhage, and the incidence of complications is low, which is worthy of clinical application.