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①目的 探讨血清中可溶性白细胞介素 2受体 (sIL 2R)在慢性乙型肝炎发病机制中的作用及临床应用价值。②方法 采用双抗体夹心酶联免疫法检测 2 81例慢性乙型肝炎病人和 16例脂肪肝病人 (其中 2 6 5例慢性乙型肝炎和 16例脂肪肝病人做了肝穿刺活组织检查 ,16例慢性重型乙型肝炎病人未做肝穿刺活组织检查 )的血清sIL 2R水平。③结果 sIL 2R水平随着肝脏组织炎症及肝纤维化的进展而增高 ,各组与对照组比较有显著性差异(F =6 .0 9,4 .0 6 ,q =2 .35～ 7.19,P <0 .0 5 ,0 .0 0 1)。④结论 慢性乙型肝炎病人血清sIL 2R的变化可作为判定肝组织炎症及纤维化病变程度的指标之一 ,可对预后作出有价值的判断 ,为治疗提供依据
Objective To investigate the role of soluble interleukin-2 receptor (sIL 2R) in the pathogenesis of chronic hepatitis B and its clinical value. Methods 2 81 cases of chronic hepatitis B and 16 cases of fatty liver were detected by double antibody sandwich enzyme-linked immunosorbent assay (256 cases of chronic hepatitis B and 16 cases of fatty liver were examined by liver biopsy, 16 Serum levels of sIL 2R in patients with chronic severe hepatitis B who did not undergo liver biopsy). Results The level of sIL 2R increased with the progress of liver inflammation and liver fibrosis. There was significant difference between each group and the control group (F = 6.09,4.06, q = 2.35 ~ 7.19, P <0 .0 5, 0 .0 0 1). ④ Conclusion Serum sIL 2R levels in patients with chronic hepatitis B can be used as an index to determine the degree of inflammation and fibrosis of liver tissue, which can make valuable judgments on prognosis and provide the basis for treatment