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对脑缺血的治疗迄今仍是一个棘手的问题,尽管不少文献均肯定亚低温疗法有保护神经的作用,但其治疗时窗仍未明确。本文作者用可逆性局灶性脑缺血大鼠模型探讨了实验性脑缺血后实施亚低温治疗的最佳时窗和最少维持时间。 实验方法 体重310～360 g雄性SD大鼠在全麻下夹闭双侧颈动脉和一侧大脑中动脉(MCA),3 h后去除MCA上的动脉夹使血流恢复。缺血前30min和缺血
The treatment of cerebral ischemia is still a thorny problem so far. Although many literatures are sure of the neuroprotective effect of mild hypothermia, the time window of treatment is still not clear. The authors used reversible focal cerebral ischemia model in rats to explore the optimal time window and the minimum maintenance time for the treatment of mild hypothermia after experimental cerebral ischemia. Experimental Methods Male Sprague Dawley rats weighing 310-360 g were used to occlude bilateral carotid arteries and one side of the middle cerebral artery (MCA) under general anesthesia. After 3 h, the artery clamps on the MCA were removed to recover the blood flow. 30min before ischemia and ischemia