论文部分内容阅读
过去的研究认为,AT—Ⅱ系体内具有强烈缩血管作用的物质,可能与肝肾综合征(HRS)的发病机理有关。近年又发现,血管内皮细胞可以合成、释放一种含21个氨基酸残基称之为内皮素(ET)的活性多肽,更具有强烈而持久的收缩血管作用,对维持机体内环境的稳定起着重要的影响。我们测定了22例HRS患者血浆ET、ANF、AT-Ⅱ的浓度并探讨了它们之间的关系,现报告如下。 材料和方法 一、对象:1993年7月～1995年7月收治的肝硬化并HRS患者22例(男20,女2)。年龄31～70岁,平均52岁。患者除有肝硬化失代偿症状和体征外,尚具有①进行性少尿;②低钠血症,③尿比重>1.020,尿常规检查改变轻微,④既往无肾脏病史;⑤尿钠<10mM/升;⑥无明显消化道出血情况,血尿素氮
Past studies suggest that AT-II system in vivo with a strong vasoconstrictor substances, may be related to the pathogenesis of hepatorenal syndrome (HRS). In recent years, it has also been found that vascular endothelial cells can synthesize and release an active polypeptide containing 21 amino acid residues called endothelin (ET), which has a strong and sustained vasoconstrictive effect and plays a role in maintaining the stability of the body environment important influence. We measured the plasma concentrations of ET, ANF and AT-II in 22 patients with HRS and explored the relationship between them, are as follows. Materials and methods First, the object: July 1993 ~ July 1995 admitted to cirrhosis and 22 patients with HRS (male 20, female 2). Age 31 to 70 years old, average 52 years old. In addition to patients with cirrhosis symptoms and signs of decompensation, but also has ① progressive oliguria; ② hyponatremia, ③ urinary specific gravity> 1.020, minor changes in urinalysis, ④ no past history of renal disease; ⑤ urinary sodium <10mM / L; ⑥ no obvious gastrointestinal bleeding, blood urea nitrogen