论文部分内容阅读
目的:探讨瘦素、脂联素之比(leptin:adiponectin,L∶A)和颈动脉内膜中层厚度(inteima-media thickness,IMT)之间的相关性。方法:随机选择110例无冠心病临床诊断的男性,分别测定血清瘦素、脂联素、IMT及其他相关指标,计算L∶A。结果:L∶A和体质指数(BMI)、收缩压、IMT、HDL-C、载脂蛋白-A(Apo-A)、血糖有明显的相关性;和年龄、舒张压、LDL-C、TG、载脂蛋白B(ApoB)、ApoA/ApoB、胰岛素浓度没有相关性;单独分析脂联素、瘦素和IMT的相关性,发现在无冠心病的男性人群中血清瘦素和IMT(r=0.301,P<0.01)有明显的相关性;以IMT为因变量,以收缩压、舒张压、HDL-C、TC、BMI、血糖、吸烟、年龄、L∶A为自变量进行多元回归分析发现:血糖、吸烟、年龄、L∶A为IMT的独立危险因素。此外,肥胖和BMI正常者L∶A比较(1.20∶0.42,P<0.001),差异有统计学意义。结论:在男性人群中L∶A较其他指标能更好的判断IMT。
Objective: To investigate the correlation between leptin, adiponectin (L: A) and carotid artery intima-media thickness (IMT). Methods: A total of 110 men without clinical diagnosis of coronary heart disease (CHD) were enrolled in this study. Serum leptin, adiponectin, IMT and other related indicators were measured and L: A was calculated. Results: There was a significant correlation between L:A and body mass index (BMI), systolic blood pressure, IMT, HDL-C, Apo-A and blood glucose; and age, diastolic blood pressure, LDL- , Apolipoprotein B (ApoB), ApoA / ApoB, and insulin concentration. The correlation between adiponectin, leptin and IMT was analyzed separately. Serum leptin and IMT were found in male subjects without coronary heart disease (r = 0.301, P <0.01). Multivariate regression analysis of systolic blood pressure, diastolic blood pressure, HDL-C, TC, BMI, blood glucose, smoking, age, : Blood sugar, smoking, age, L: A is an independent risk factor for IMT. In addition, obesity and normal BMI L: A comparison (1.20:0.42, P <0.001), the difference was statistically significant. CONCLUSIONS: L: A is a better predictor of IMT than other measures in men.