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目的:探讨扶正中药对活动性肺结核患者细胞免疫功能的调节作用。方法:治疗组60例除常规抗痨治疗以外,加用扶正中药。另外随机设置对照组50例,只作常规抗痨治疗。分别于治疗前后测定外周血T亚群CD3+、CD4+、CD8+及4/8比值,将所得结果分别与标准对照组(30例)、两组之间进行多项次比较。结果:①活动性肺结核患者细胞免疫功能受损较重,CD3+、CD4+均减少,主要是CD4+减少;②治疗后细胞免疫功能均有恢复,但未能达到正常水平;③加用扶正中药后,各项免疫学指标的恢复和临床症状的改善明显优于对照组。结论:扶正中药对活动性肺结核患者失调的细胞免疫功能有较好的疗效,值得临床应用。
Objective: To explore the regulatory effect of Fuzheng Chinese medicine on cellular immune function in patients with active pulmonary tuberculosis. Methods: In the treatment group, in addition to routine anti-tuberculosis treatment, 60 cases were added with the righting and strengthening of Chinese medicine. In addition, 50 patients in the control group were randomized and only routine anticonvulsant therapy was performed. The ratios of CD3+, CD4+, CD8+, and 4/8 in T subgroups of peripheral blood were measured before and after treatment, and the results were compared with the standard control group (30 cases) and the two groups respectively. RESULTS: 1 The cellular immune function of patients with active tuberculosis was severely impaired, CD3+ and CD4+ were decreased, mainly CD4+ was decreased; 2 the cellular immune function was restored after treatment, but it failed to reach normal level; 3 After adding the righting medicine, The recovery of various immunological parameters and the improvement of clinical symptoms were significantly better than those of the control group. Conclusion: Fuzheng Chinese medicine has good curative effect on the imbalanced cellular immune function in patients with active pulmonary tuberculosis, and it is worthy of clinical application.