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目的探讨耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)在新生儿败血症中的分布及耐药特点,为临床治疗提供参考。方法应用全自动血培养系统(BACTEC-9120),VITEK-AMS细菌鉴定仪,对120例MRCNS感染新生儿败血症血培养进行细菌鉴定,采用K-B纸片扩散法测定MRCNS对青霉素等18种抗生素的耐药性。结果120株MRCNS中表皮葡萄球菌56株占46.7%,溶血葡萄球菌30株占25%,人葡萄球菌12株占10%,沃氏葡萄球菌9株占7.5%,其它葡萄球菌13株占10.8%。药敏结果显示MRCNS多重耐药。结论凝固酶阴性葡萄球菌(CNS)已成为新生儿血培养的第一检出菌,主要为表皮葡萄球菌和溶血葡萄球菌,MRCNS占主导地位,成为新生儿院内感染的主要致病菌,药敏显示MRCNS为多重耐药,治疗可选用糖肽类和碳青霉烯类。MRCNS所致的院内感染值得引起关注。
Objective To investigate the distribution and drug resistance of methicillin-resistant coagulase-negative staphylococci (MRCNS) in neonatal sepsis and provide a reference for clinical treatment. Methods The blood cultures of 120 MRCNS neonates with septicemia were identified by automatic blood culture system (BACTEC-9120) and VITEK-AMS bacterial identification instrument. KB culture was used to determine the resistance of MRCNS to 18 antibiotics such as penicillin Medicinal properties. Results The results showed that Staphylococcus epidermidis accounted for 46.7% in 120 MRCNS strains, 30 strains of Staphylococcus haemolyticus accounted for 25%, 12 strains of Staphylococcus aureus accounted for 10%, 9 strains of Staphylococcus waukesu accounted for 7.5% and 13 strains of Staphylococcus aureus accounted for 10.8% . Susceptibility results show MRCNS multi-drug resistance. Conclusion Coagulase-negative staphylococci (CNS) has become the first detection of neonatal blood culture, mainly Staphylococcus epidermidis and Staphylococcus haemolyticus, MRCNS dominates and become the main pathogen of neonatal nosocomial infection, drug sensitivity MRCNS showed multiple drug resistance, the treatment of choice of glycopeptides and carbapenems. Nosocomial infections caused by MRCNS deserve attention.