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目的：研究IgA肾病时肾小囊足细胞的病变。方法：用右旋糖酥（69.447ku）诱发小鼠IgA肾病。结果：荧光显微镜下实验组小鼠肾小球内有颗粒状免疫复合物沉积，透射电镜下出现IgA肾病的典型病变。同时，足细胞胞体和突起内出现大量空泡，微丝及粗面内质网稀疏散在。有些突起回缩；有些初级突起细长，直接以其膨大的末端附着于毛细血管基膜。在透射电镜及扫描电镜下皆常见有明显的足突融合。结论：IgA肾病时，病变波及厅小囊足细胞。
Objective: To study the pathological changes of renal podocyte in IgA nephropathy. Methods: Mouse IgA nephropathy was induced with dextrose (69.447 ku). Results: Under the fluorescence microscope, there were granular immune complexes in the glomerulus and typical lesions of IgA nephropathy under transmission electron microscope. At the same time, a large number of vacuoles appeared in the somatic cell body and protuberances, and the microfilaments and rough endoplasmic reticulum were sparsely scattered. Some protuberances contract; some primary protuberances slender and attach directly to the capillary basement membrane with their enlarged ends. In transmission electron microscopy and scanning electron microscopy are common obvious foot process fusion. Conclusion: In IgA nephropathy, the lesion affects the parietal podocytes.