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A simplified approach is presented to analyze the single pile settlement in multilayered soil. First, a fictitious soil?pile model is employed to consider the effect of layered soil beneath pile toe on pile settlement behavior. Two approximation methods are proposed to simplify the nonlinear load transfer function and simulate the nonlinear compression of fictitious soil?pile, respectively. On this basis, an efficient program is developed. The procedures for determining the main parameters of mathematical model are discussed. Comparisons with two well-documented field experimental pile loading tests are conducted to verify the rationality of the present method. Further studies are also made to evaluate the practicability of the proposed approach when a soft substratum exists, and the results suggest that the proposed method can provide a constructive means for assessing the settlement of a single pile for use in engineering design.