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一、前言廿多年前,四环素被发现后不久,便作为有效的广谱抗菌素在临床上获得了较为广泛的应用;并自六十年代以来,确认四环素荧光法对于筛选恶性肿瘤为一种较为有效的工具,继而在胃癌检查方面得到了应用。因此,不仅在药物学、生理学及临床医学方面,特别在癌诊断方面要求对四环素进行深入的研究,这些要求借助于放射性同位素得以有效的进行。迄今为止,曾提出了以~(131)I、~(99m)Tc、~(14)C以及~3H等放射性同位素标记的四环
I. INTRODUCTION Twenty years ago, tetracycline was widely used clinically as an effective broad-spectrum antimicrobial agent shortly after its discovery. Since the 1960’s, it has been confirmed that tetracycline fluorometry is a more effective method for the screening of malignant tumors Of the tools, followed by gastric cancer screening has been applied. Therefore, tetracycline research is required not only in pharmacology, physiology and clinical medicine, but also in cancer diagnosis, and these requirements are effectively carried out by means of radioisotopes. Up to now, it has been proposed to use ~ (131) I, ~ (99m) Tc, ~ (14) C and ~ 3H and other radioactive isotope labeled tetracyclic