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目的:了解抗菌药引起的药品不良反应(ADR)的发生特点。方法:回顾性分析我院2007年12月～2010年12月临床科室自发呈报的268例抗菌药所致不良反应报告,对引起不良反应的药品、给药途径、临床表现、患者年龄、性别、不良反应史等方面进行统计分析。结果:268例抗菌药不良反应报告中中老年人比例最大,占59.70%;给药途径以静脉滴注为主,占78.36%;以头孢菌素类ADR比例最高,占53.73%;主要的不良反应为皮肤及附件损害,占47.76%。结论:应高度重视抗菌药不良反应,合理用药,避免或减少ADR的发生。
Objective: To understand the characteristics of anti-bacterial drug-induced adverse reactions (ADR). Methods: A retrospective analysis of our hospital from December 2007 to December 2010 spontaneous reporting of clinical departments of 268 cases of adverse reactions caused by antibacterial drugs, adverse reactions caused by drugs, route of administration, clinical manifestations, patient age, gender, Adverse reaction history and other aspects of statistical analysis. Results: 268 cases reported the largest proportion of ADRs, accounting for 59.70%; intravenous drip was the main route of administration, accounting for 78.36%; the highest proportion of cephalosporin ADR, accounting for 53.73%; the main adverse Response to skin and accessories damage, accounting for 47.76%. Conclusion: Antibacterial agents should be attached great importance to adverse reactions, rational use of drugs to avoid or reduce the occurrence of ADR.