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目的:评价我院器官移植中心肝移植患者术后早期抗感染药的应用情况及合理性。方法:调查我院2005年9～12月50例肝移植患者术后1月内抗感染药的应用状况,结合其应用例/次、应用时间、药物利用指数(DUI)及药物联用与病原学相符情况,分析其应用的合理性。结果:肝移植术后1月内应用频率列前10位的抗感染药中,DUI≤1的有9个,DUI>1的1个;围手术期抗菌药物应用率达100%;联合用药中,单用2例(占4%),二联应用17例(占34%),三联应用21例(占42%),四联以上应用10例(占20%)。结论:我院术后抗感染药应用剂量和联合用药比例均偏高,亟待干预。
Objective: To evaluate the application and rationality of early postoperative anti-infectives in liver transplant recipients in our hospital. Methods: To investigate the application of anti-infectives in 50 patients with liver transplantation within one month after operation in our hospital from September to December in 2005. Combined with the application cases / times, application time, drug use index (DUI) and drug combination with pathogen Learn the match, analyze the rationality of its application. Results: In the first 10 months after liver transplantation, among the top 10 anti-infectives, there were 9 with DUI≤1 and 1 with DUI> 1. The rate of perioperative antibacterials was 100% , 2 cases (4%), 17 cases (34%), 21 cases (42%), and 10 cases (20%). Conclusion: The dosage of anti-infectives and the proportion of combination therapy in our hospital are both high and require intervention.