Synthesis and preliminary biological evaluation of the derivatives of O6-benzylguanine as inactivato

• 作 者: Lei Zhang Bing Jia Chang Feng
• 机 构: The State Key Laboratory of Natural and Biomimetic Drags,Medical and Healthy Analysis Center,Medical
• 出 处: 中国化学快报（英文版）
• 发表日期: 2004年期
• 关键词: O6-BG derivatives AGT inactivator

A series of new O6-BG derivatives (14-21,23-30) were synthesized as inactivators of O6-Alkylguanine-DNA alkyltransferase (AGT),and their ability to inhibit AGT was preliminary evaluated by MTT with O6-BG as the control.The result suggested compound 30 displayed a higher activity than O6-BG.