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采用Ｌ９２９细胞作为靶细胞，对约氏疟原虫感染小鼠血清的细胞毒活性（ＣＡ）进行了测定。结果：持续疟原虫感染鼠血清在感染后第３ｄ即出现轻度的ＣＡ，至感染后第８～１５ｄＣＡ达到较高水平（３５％～４０％），以后逐渐下降，１个月时仍有２０％的ＣＡ。仅感染疟原虫７ｄ的鼠血清，高水平ＣＡ维持时间较短，感染后１５ｄＣＡ尚存留１７．８％，１个月后仅有６％。在小鼠感染疟原虫后第８ｄ注射大肠杆菌内毒素（ＬＰＳ），可迅速增强感染鼠血清的ＣＡ，此活性在注射ＬＰＳ后６０ｍｉｎ达高峰，１５０ｍｉｎ后下降至未注射ＬＰＳ的持续感染鼠水平。提示：疟原虫感染鼠血清具有一定的抗肿瘤细胞活性，此活性可以被ＬＰＳ协同增强。
Using L929 cells as target cells, the cytotoxic activity (CA) of the serum of Plasmodium yoelii infected mice was measured. Results: The serum of mice infected with Plasmodium continuously showed mild CA on the 3rd day after infection, reached a high level (35% -40%) on the 8th to the 15th day after infection, and then gradually decreased after one month. % Of CA. Rats infected with Plasmodium only for 7 days had a shorter duration of high-level CA administration, with 17.8% remaining on day 15 after infection and only 6% after 1 month. Infection of E. coli lipopolysaccharide (LPS) on the 8th day after challenge with P. falciparum in mice significantly increased the CA level in infected rat serum, which peaked at 60 min after injection of LPS and dropped to sustained level after 150 min in mice without LPS injection. Tip: Plasmodium infection in mouse serum has anti-tumor cell activity, this activity can be synergistically enhanced LPS.