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建立门控９９ｍＴｃ-甲氧基异丁基异腈心肌灌注断层显像的定量分析方法．方法：计算室壁收缩分数（ＷＣＦ）和功能低下面积（ＤＦＡ），直接反映心脏整体和局部的心肌收缩功能，并以ＷＣＦ功能曲线及其靶心图显示．结果：ＷＣＦ和ＤＦＡ的测定重复性很好，ＣＶ分别为３．３０％和３．６％．ＷＣＦ、几何法测量的ＥＦ和ＤＦＡ呈负相关（ｒ分别为-０．８５６３和-０．８３９０）．门控心肌断层显像法与心室显像计数法测量的ＥＦ值相关性好（ｒ＝０．８９０７）．正常人、冠心病和心肌梗塞患者的ＷＣＦ值分别为０．４３８±０．０３０、０．３０６±０．０８１和０．２８９±０．０９５．左前降支、右冠状动脉、左冠状动脉回族支和多支冠状动脉分布区灌注低下患者的ＷＣＦ值分别为０．２８１±０．０７７、０．３１９±０．０７１、０．３０３±０．０６６和０．２４８±０．１０６．前三者之间差异无显著性（Ｐ＞０．０５），但后者低于前三者（Ｐ＜０．０５）．平衡心室显像测量ＥＦ值、门控心肌显像测量ＥＦ值和ＷＣＦ值对冠心病的诊断灵敏度分别为７２．４％、４８．３％和８２．８％．结论：门控心肌断层显像测量ＷＣＦ值、ＷＣＦ功能曲线及其靶心图能全面客观地评价心脏收缩功能．
To establish a quantitative method for gated 99mTc-methoxyisobutylisonitrile myocardial perfusion tomography. Methods: The WCF and DFA were calculated, which directly reflected global and local myocardial systolic function. The WCF curve and its bull’s-eye plot were also displayed. Results: The determination of WCF and DFA was very good with CVs of 3.30% and 3.6% respectively. WCF, the geometric mean EF and DFA were negatively correlated (r = -0.8563 and -0.8390, respectively). The correlation between gated myocardial perfusion imaging and EF measured by ventricular imaging was good (r = 0.8907). The WCF of normal subjects, patients with coronary heart disease and myocardial infarction were 0.438 ± 0.030, 0.306 ± 0.081 and 0.289 ± 0.095, respectively. The WCF values of left anterior descending branch, right coronary artery, Hui branch of left coronary artery and perfusion of multi-branch coronary artery were 0.281 ± 0.077,0.319 ± 0.071 and 0.303 ± 0 respectively. 066 and 0.248 ± 0.106. There was no significant difference between the former three groups (P> 0.05), but the latter was lower than the former three groups (P <0.05). The diagnostic sensitivity of balanced ventricular imaging for EF, WF and WCF for coronary heart disease were 72.4%, 48.3% and 82.8%, respectively. CONCLUSION: WCF value is measured by gated myocardial imaging, and the WCF function curve and its bull’s-eye plot can evaluate cardiac systolic function in a comprehensive and objective way.