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【目的】研究慢性乙型肝炎患者HBV复制水平与病情活动关系。【方法】采用荧光标记定量PCR的方法,测定一组急性发作的慢性乙型肝炎患者(其中HBeAg阳性组38例,抗HBe阳性组22例)病情活动期和恢复期的血清HBVDNA含量。【结果】血清HBVDNA含量在活动期明显高于恢复期(P<005)。血清HBVDNA含量与丙氨酸转氨酶(ALT)、门冬氨酸转氨酶(AST)及总胆红素(TBLLI)之间无相关性。【结论】HBVDNA复制水平与慢性乙型肝炎的活动密切相关。
【Objective】 To investigate the relationship between HBV replication and disease activity in patients with chronic hepatitis B 【Method】 Fluorescence quantitative PCR was used to detect the serum HBVDNA in a group of patients with chronic hepatitis B (38 in HBeAg-positive and 22 in HBeAg-positive) during active stage and convalescent stage. 【Result】 Serum HBVDNA content was significantly higher than that of convalescence stage (P <0.05). Serum HBVDNA content and alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin (TBLLI) no correlation between. 【Conclusion】 The level of HBVDNA replication is closely related to the activity of chronic hepatitis B.