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目的:总结国外关于表皮生长因子受体(EGFR)通过各种信号通路调节DNA修复导致辐射抗拒相关机制的研究进展。方法:应用PubMed数据库系统,以“表皮生长因子受体、信号通路、DNA损伤修复、放射抗拒”为关键词检索2005-01-2011-12的相关文献,共检索到英文文献198篇。纳入标准:1)EGFR的表达;2)辐射抗拒和DNA损伤修复机制;3)EGFR和辐射诱导的DNA损伤修复;4)EGFR信号通路调控DNA损伤修复导致放射抗拒的可能机制。根据纳入标准,纳入分析22篇文献。结果:EGFR过表达与放化疗抗拒相关。它可以通过联接DNA蛋白激酶催化亚单位(DNA-PKcs)来调节放疗诱导的DNA损伤的修复。EGFR及其对DNA修复能力之间的分子连接可能通过该受体的一个或多个下游信号通路介导。结论:EGFR作为调节DNA损伤修复机制的信号通路与放射抗拒之间存在相关性,靶向于其中激活的信号通路可以为改善放射抗拒提供新的治疗思路。
OBJECTIVE: To summarize the research progress of foreign mechanisms about the mechanism of EGFR regulating DNA repair through various signaling pathways. METHODS: The PubMed database system was used to search for articles related to “epidermal growth factor receptor, signaling pathway, DNA damage repair and radiation resistance” from January 2005 to December 2011 with 198 articles in English. Inclusion criteria: 1) EGFR expression; 2) radiation resistance and DNA damage repair mechanisms; 3) EGFR and radiation-induced DNA damage repair; 4) EGFR signaling pathway regulates the possible mechanism by which DNA damage repair leads to radioresistance. According to the inclusion criteria, 22 articles were included in the analysis. Results: Overexpression of EGFR was associated with resistance to chemoradiotherapy. It can regulate radiotherapy-induced DNA damage repair by linking the catalytic subunit of DNA kinase (DNA-PKcs). The molecular link between EGFR and its ability to repair DNA may be mediated through one or more downstream signaling pathways of the receptor. CONCLUSION: There is a correlation between EGFR as a signal pathway regulating DNA damage repair mechanism and radiation resistance. Targeting the activation of EGFR signaling pathway may provide a new therapeutic approach for improving radiation resistance.