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目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)合并高血压患者血清一氧化氮(NO)、血浆内皮素-1(ET-1)及内皮微粒(EMP)的水平变化及其相关性,为OSAHS合并高血压的早期预防和治疗提供依据。方法选择2016年1月至12月在吉林大学第一医院就诊的OSAHS患者80例:单纯OSAHS患者(单纯OSAHS组)40例,其中男性32例,女性8例,年龄(54.5±7.8)岁;合并高血压患者(合并高血压组)40例,其中男性33例,女性7例,年龄(54.2±7.3)岁。对照组为30例健康体检者,其中男性24例,女性6例,年龄(54.2±7.5)岁。分别采用比色法检测NO,双抗体夹心法检测ET-1,流式细胞技术检测EMP。结果合并高血压组、单纯OSAHS组ET-1、EMP水平均显著高于对照组(P<0.01),NO低于对照组(P<0.01);对照组、单纯OSAHS组、合并高血压组ET-1水平依次升高(F=19.661,P<0.01),EMP水平亦依次升高(F=606.748,P<0.01),NO依次降低(F=61.601,P<0.01);合并高血压组EMP与ET-1正相关(r=0.841,P<0.05),与NO负相关(r=-0.944,P<0.05);单纯OSAHS组EMP与ET-1正相关(r=0.780,P<0.05),与NO负相关(r=-0.897,P<0.05)。结论 OSAHS患者合并高血压与ET-1、EMP、NO水平有关,联合监测上述指标早期改善OSAHS患者通气功能,能够评估OSAHS并发高血压的发生,为临床治疗提供参考。
Objective To investigate the changes of serum nitric oxide (NO), endothelin-1 (ET-1) and endothelial cell (EMP) levels in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) To provide the basis for the early prevention and treatment of OSAHS complicated with hypertension. Methods Eighty OSAHS patients were enrolled in the First Hospital of Jilin University from January 2016 to December 2016. The study included 40 patients with OSAHS (simple OSAHS group), including 32 males and 8 females, with an average age of 54.5 ± 7.8 years. Forty patients with hypertension (with hypertension group), including 33 males and 7 females, were 54.2 ± 7.3 years old. The control group consisted of 30 healthy subjects, including 24 males and 6 females, with a mean age of 54.2 ± 7.5 years. NO was detected by colorimetric assay, ET-1 by double antibody sandwich method, and EMP by flow cytometry. Results The levels of ET-1 and EMP in OSAHS group were significantly higher than those in control group (P <0.01), and NO was lower in control group, OSAHS group alone, and ET-1 (F = 61.601, P <0.01). The levels of EMP in hypertensive group were significantly higher than those in control group (F = 19.661, P <0.01) (R = -0.944, P <0.05). There was a positive correlation between EMP and ET-1 in OSAHS group (r = 0.780, P <0.05) , Negatively correlated with NO (r = -0.897, P <0.05). Conclusion OSAHS patients with hypertension and ET-1, EMP, NO levels related to the combined monitoring of these indicators early to improve ventilation in patients with OSAHS function, can assess the incidence of OSAHS complicated with hypertension, provide a reference for clinical treatment.