论文部分内容阅读
１９９２年１０月～１９９５年６月共进行卵巢早衰（ＰＯＦ）２２例３１周期卵子赠送。供者采用ＧｎＲＨ－ａ／ＨＭＧ／ｈＣＧ超排卵方案，受者采用外源性类固醇激素替代治疗（ＨＲＴ），周期第２１天行子宫内膜活检，选择子宫内膜分泌期病例采用受者丈夫精子于ＨＲＴ第１５～２０天进行体外授精和胚胎移植（ＩＶＦ－ＥＴ）。结果：临床妊娠率３６％（１１／３１），双胎妊娠４例，单胎任娠７例，１９９４年ｌ月１４日诞生国内首例ＰＯＦ卵子赠送新生儿，目前继续妊娠３例，流产６例。完整卵泡簇供卵组较ＩＶＦ－ＥＴ剩余卵子供卵组在移植胚胎数目、胚胎评分、移植后妊娠率显著提高，分别为Ｐ＜０．０５、＜０．００１及＜０．０５；而流产率显著降低，Ｐ＜０．００１；受卵者年龄＜３０岁组和＞３０组在移植胚胎数目和胚胎评分无显著差异（Ｐ均＞０．０５），而临床妊娠率分别为４２％和３２％，存在明显差异（Ｐ＜０．０５）。在ＨＲＴ第１６～１８天移植胚胎获得妊娠率较高（９／２２），大于ＨＲＴ第２０天或胚胎发育与子宫内膜发育相差超过±２天无妊娠病例。以上结果提示：ＨＲＴ和卵子赠送是ＰＯＦ患者获得妊娠的有效方法；卵子质量是影响胚胎发育、移植后妊娠率及自然流产率的重要因素；子宫内?
October 1992 ~ June 1995 a total of 22 cases of ovarian premature aging (POF) 31 cycles of eggs presented. The donor was treated with GnRH-a / HMG / hCG superovulation. The recipients were treated with exogenous steroid hormone replacement therapy (HRT) and endometrial biopsy on the 21st day of the cycle. In vitro fertilization and embryo transfer (IVF-ET) were performed on days 15-20 of HRT. Results: The clinical pregnancy rate was 36% (11/31), twin pregnancy in 4 cases, single pregnancy in 7 cases, the birth of the first POF egg on January 14, 1994, giving birth to newborns, 3 cases of current pregnancy, abortion 6 example. The number of embryos transferred, the embryo score and the pregnancy rate after transplantation were significantly increased in the group of intact egg follicles as compared with that of the remaining IVF-ET group (P <0.05, <0.001 and <0.05 respectively) (P <0.001). There was no significant difference in embryo numbers and embryo scores between recipients of age <30 years and> 30 (P> 0.05), while clinical pregnancy rates were 42% and 32%, there is a significant difference (P <0.05). The pregnancy rate was higher (9/22) on the 16th to 18th days of HRT transplants, more than the HRT on the 20th day or between embryonic development and endometrial development more than ± 2 days without pregnancy. The above results suggest that: HRT and egg donation is an effective method for pregnancy in POF patients; egg quality is an important factor affecting embryonic development, pregnancy rate after pregnancy and spontaneous abortion; intrauterine?