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目的观察抗生素阿莫西林、甲硝唑与H2受体阻滞剂雷尼替丁不同组合应用对合并幽门螺杆菌（Hp）的十二指肠溃疡治疗效果．方法经电子纤维内镜检查诊断为十二指肠溃疡合并Hp阳性的门诊患者82例，随机分配为单用抗生素组、单用H2受体阻滞剂组和抗生素与H2受体阻滞剂联合用药三组．单用抗生素组82例，女3例，男25例，年龄18岁～34岁，平均28．1岁，病程6mo～5a，平均3．5a；单用H2受体阻滞剂组27例，女3例，男24例，年龄19岁～37岁，平均4．1a；抗生素与H2受体阻滞剂联合用药组27例，女4例，男23例，年龄18岁～36岁，平均27．8岁，病程4mo～4．5a，平均4．2a．单用抗生素组，采用3次／d口服，每次服用阿莫西林500mg和甲硝唑200mg，单用H2受体阻滞剂组，采用2次／d口服，每次服用雷尼替丁150mg治疗．抗生素与H2受体阻滞剂联合用药组，采用3次／d口服，每次服用阿莫西林500mg和甲硝唑200mg联合2次／d，每次口服雷尼替丁150mg治疗．4wk一疗程．疗程结束后，对患者的临床症状改善和溃疡愈合情况进行分析．结果单用抗生素组，症状完全缓解，溃疡灶由活动期转为疤痕期，即治愈18例（64．29％）；症状基本缓解，溃疡灶由活动期转为愈合期，即好转7例（25．00％）；症状仍存在，溃疡灶仍处于活动期，即无效3例（10．7
Objective To observe the therapeutic effect of different combinations of antibiotics amoxicillin, metronidazole and H2 receptor blocker ranitidine on duodenal ulcer with Helicobacter pylori (Hp). Methods Eighty-two outpatients with duodenal ulcer and Hp positive diagnosed by electronic fiber endoscopy were randomly assigned to single antibiotic group, H2 antagonist alone group and antibiotics combined with H2 receptor blocker Three groups of drugs. Antibiotic group alone 82 cases, 3 females, 25 males, aged 18 years to 34 years, mean 28.1 years, duration of 6mo ~ 5a, an average of 3.5a; H2 receptor blocker alone 27 cases, 3 females, 24 males, aged 19 years to 37 years, an average of 4.1a; antibiotics and H2 receptor blocker combination group of 27 patients, 4 females, 23 males, aged 18 years to 36 years, mean 27.8 years old, duration of 4mo ~ 4.5a, an average of 4.2a. Antibiotic alone group, with 3 times / d orally, each taking amoxicillin 500mg and metronidazole 200mg, H2 receptor blocker alone, with 2 times / d orally, each taking ranitidine 150mg treatment. Antibiotics and H2 receptor blockers combined with oral administration of 3 times / d, each taking amoxicillin 500mg and metronidazole 200mg 2 times / d, ranitidine 150mg oral treatment. 4wk a course of treatment. After the course of treatment, the patient’s clinical symptoms and ulcer healing were analyzed. Results In the group of antibiotics alone, the symptom was completely relieved and the ulcer lesion was changed from the active stage to the scar stage, that is, 18 cases (64.29%) were cured; the symptoms were basically relieved; the ulcer lesion was changed from active stage to healing stage, 25.00%); symptoms still exist, ulcer lesions are still active, that is invalid in 3 cases (10.7