【摘 要】
：
Metastasis is the main cause of mortality in patients with cancer.Epithelial-mesenchymal transition (EMT),a crucial process in cancer metastasis,is an established target for antimetastatic drug development.LFG-500,a novel synthetic flavonoid,has been reve
【机 构】
：
Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy,Jiangsu Center for the Collaborati
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Metastasis is the main cause of mortality in patients with cancer.Epithelial-mesenchymal transition (EMT),a crucial process in cancer metastasis,is an established target for antimetastatic drug development.LFG-500,a novel synthetic flavonoid,has been revealed as a potential antitumor agent owing to its various activities,including modulation of EMT in the inflammatory microenvironment.Here,using a transforming growth factor beta (TGF-β)-induced EMT models,we found that LFG-500 inhibited EMT-associated migration and invasion in human breast cancer,MCF-7,and lung adenocarcinoma,A549,cell lines,consistent with the observed downregulation of YAP activity.Further studies demonstrated that LGF-500-induced suppression of YAP activation was mediated by integrin-linked kinase (ILK),suggesting that the ILK/YAP axis might be feasible target for anti-EMT and antimetastatic treatments,which was verified by a correlation analysis with clinical data and tumor specimens.Hence,our data support the use of LGF-500 as an antimetastatic drug in cancer therapy and provide evidence that the ILK/YAP axis is a feasible biomarker of cancer progression and a promising target for repression of EMT and metastasis in cancer therapy.
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