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N(β-二乙胺乙基)-N-邻甲苯基-3′,4′,5′三甲氧基苯甲酰胺马来酸盐(简称603)系我院合成药化教研室设计合成的一个新型化合物,对氯仿、乌头碱和哇巴因三种心律失常模型均有显著的抗心律失常作用;但在狗的亚急性毒性试验中出现短暂的四肢震颤,强直性抽搐,或阵发性惊厥,因而需要寻找拮抗药物。我们观察了安定、香草醛和心得安对603惊厥作用和疗效的影响。结果表明603与安定、香草醛或心得安联合用药,
N (β-diethylaminoethyl) -N-o-tolyl-3 ’, 4’, 5 ’trimethoxybenzamide maleate (referred to as 603) Department of synthetic medicine in our hospital design and synthesis of a New compounds, chloroform, aconitine and ouabain three arrhythmia models have significant anti-arrhythmic effect; but in the dog subacute toxicity test showed transient limb tremor, tonic convulsions, or paroxysmal Convulsions, which need to find antagonists. We observed the effects of diazepam, vanillin and propranolol on the convulsive effect of 603 and efficacy. The results show that 603 and stability, vanillin or propranolol combination therapy,