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目的分析出生缺陷儿临床状况。方法对1990年至2009年本院住院分娩的21 050例围产儿资料分析,并对204例出生缺陷儿的临床资料进行研究。结果出生缺陷的发生率为9.69‰,出生缺陷前五位排序为:颌面五官畸形、肌肉骨骼系统畸形、心血管系统畸形(含先天性心脏病)、神经管畸形、消化系统畸形。与孕早期有不良病史(服药、接触有毒有害物质、噪音)相关的有72.55%,与烟酒吸毒等不良嗜好相关的有6.37%,与不良产史相关的有21.08%。结论“关口”前移、筛查普遍、治疗优先,防止出生缺陷,提高人口素质。
Objective To analyze the clinical status of birth defects. Methods The data of 21 050 cases of perinatal delivery in our hospital from 1990 to 2009 were analyzed and the clinical data of 204 cases with birth defects were studied. Results The incidence of birth defects was 9.69 ‰. The top five birth defects were maxillofacial deformities, musculoskeletal system deformities, cardiovascular system deformities (including congenital heart disease), neural tube defects and digestive system deformities. 72.55% were related to bad medical history (medication, exposure to toxic and harmful substances, noises) during the first trimester, 6.37% were related to the bad habits such as smoking and drinking and drug abuse, and 21.08% were related to the history of bad production. Conclusion “mark ” advance, screening, treatment priority, to prevent birth defects, improve the quality of the population.