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目的对人工流产中使用米索前列醇的安全性及临床效果进行研究,证实米索前列醇能够有效地软化宫颈且有较好的安全性。方法以我院门诊2010年3月～2011年3月人工流产的38例患者为研究对象,随机分为两组,每组19例,观察组患者在术前6h将0.2mg米索前列醇置于阴道后穹隆或术前1h将0.2mg的米索前列醇由肛门塞入;对照组患者在术前10h由宫颈宫腔放置16～18号橡皮导管,进行宫颈扩张。对两组患者的宫颈扩张程度、手术时间、出血量、不良反应及人流综合症发生率进行比较。结果两组患者的宫口均能放入7号吸管,宫颈扩张程度良好,均满足人流术的要求。观察组患者的宫颈扩张程度、手术时间、出血量、不良反应及人流综合症发生率均较对照组有明显优势,且子宫收缩良好,无须使用缩宫药物。结论人工流产术前通过阴道或肛门置入米索前列醇,可以有效地扩张宫颈,缩短手术时间,减少出血,降低不良发及人流综合症发生率等优势,适于临床推广使用。
Objective To study the safety and clinical efficacy of misoprostol in induced abortion, confirming that misoprostol can effectively soften cervix and have better safety. Methods Thirty-eight cases of induced abortion in our hospital from March 2010 to March 2011 were randomly divided into two groups (n = 19 in each group). Patients in the observation group were treated with 0.2 mg misoprostol In the vaginal posterior fornix or preoperative 1h 0.2mg of misoprostol into the anus; control group patients 10h before surgery by the cervix uterus placed 16 to 18 rubber catheter for cervical dilatation. The two groups of patients with cervical dilatation, operative time, bleeding volume, adverse reactions and the incidence of people-oriented syndrome were compared. Results The uterine orifice of both groups of patients could be put into No. 7 straw, and the degree of cervical dilatation was good, all of which satisfied the requirements of abortion. The observation group patients with cervical dilatation, operation time, blood loss, adverse reactions and the incidence of flow syndrome were significantly superior to the control group, and the uterus contractions good, without the use of contraction medicine. Conclusions Inserting misoprostol through the vagina or anus before artificial abortion can effectively expand the cervix, shorten the operation time, reduce the bleeding and reduce the incidence of unhealthy hair and human flow syndrome. It is suitable for clinical use.