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目的:分析风湿病合并药物性肝损伤的临床类型、用药分布和短期临床疗效。方法:从本院2013年1月-2014年12月住院的风湿病患者中收集发生药物性肝损害的病例,共157例,对患者的基础疾病、用药史、肝损害分型及治疗预后进行回顾性分析。结果:风湿病合并药物性肝损伤患者中系统性红斑狼疮占15.92%;类风湿性关节炎占36.31%;强直性脊柱炎占9.55%;其他风湿病占38.21%;肝损伤类型以肝细胞损伤型为主(肝细胞损伤型占65.6%,胆汁淤积型占37.39%,混合型占7.01%);16.56%的患者治愈(26例),79.62%的患者好转(125例),3.18%的患者无效(5例),0.64%的患者死亡(1例,患者死于心源性猝死)。结论:风湿病合并药物性肝损伤的临床分型以肝细胞损伤型为主,大多数患者经治疗后临床结局良好。
OBJECTIVE: To analyze the clinical types, drug distribution and short-term clinical efficacy of rheumatoid arthritis with drug-induced liver injury. Methods: A total of 157 cases of drug-induced liver damage were collected from hospitalized patients with rheumatic diseases from January 2013 to December 2014 in our hospital. The patients were divided into basic diseases, medication history, liver damage classification and treatment prognosis Retrospective analysis. Results: Rheumatoid arthritis patients with systemic lupus erythematosus accounted for 15.92%, rheumatoid arthritis accounted for 36.31%, ankylosing spondylitis accounted for 9.55%, other rheumatism accounted for 38.21%, and the type of liver injury was hepatocellular injury (65.6% for hepatocellular injury, 37.39% for cholestasis and 7.01% for mixed); 16.56% were cured (26), 79.62% were improved (125), 3.18% Invalid (5), 0.64% of patients died (1 patient died of sudden cardiac death). Conclusion: The clinical classification of rheumatism complicated with drug-induced liver injury is mainly hepatocellular injury. Most patients have good clinical outcomes after treatment.