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目的 探讨持续静脉滴注安定法治疗频繁发作小儿癫痫的疗效。方法 对 2 8例频繁发作癫痫的患儿 ,采用安定持续静脉滴注 ,按发作情况调整滴注速度 ,比较治疗前后的发作频率 ;应用荧光偏振免疫法测定血安定浓度。结果 持续静脉滴注安定治疗后每日发作次数较治疗前明显减少 (P <0 .0 1)。血安定浓度的安全有效范围为 5 74 .5 0± 2 91.5 7μg/ml。安定静脉滴注速度与血药浓度呈正相关 (γ =0 .94 1,P <0 .0 1)。 结论 持续静脉滴注安定是一种安全有效的控制小儿频繁发作癫痫的辅助治疗方法
Objective To investigate the efficacy of continuous intravenous infusion of diazepam in the treatment of frequent seizures in children with epilepsy. Methods Twenty-eight children with seizure-prone epilepsy were given continuous infusion of diazepam and the infusion rate was adjusted according to the onset of seizures. The frequency of seizures was compared before and after treatment. The concentration of diazepam was determined by fluorescence polarization immunoassay. Results The number of daily attacks after continuous intravenous infusion of diazepam was significantly lower than that before treatment (P <0.01). The safe and effective range of blood concentration was 5 74 .50 ± 2 91.5 7μg / ml. The stability of intravenous infusion rate and plasma concentration was positively correlated (γ = 0.941, P <0.01). Conclusions Continuous intravenous infusion of diazepam is a safe and effective adjuvant therapy for controlling seizures in children with frequent seizures