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目的 研究肝硬变不同分期的临床病理意义．方法 肝硬变活检标本４５６ 例，用ＨＥ、组化、免疫组化及电镜技术进行研究．结果 按照其组织病理学表现可分为早、中、晚期肝硬变，而后者又可分为Ａ，Ｂ，Ｃ 三种病理学表现型． 提示其间不仅组织学形态有别，而且假小叶纤维带网状、胶原、弹力纤维及ＦＮ，ＬＮ，ⅣＣｏ 也有差异（ Ｐ＜ ０－０１） ，纤维带αＳＭＡ 及ⅧＦ Ａｇ 示强阳性表达，表明以血管平滑肌纤维占优势． 随访肝活检提示，早期肝硬变逆转为慢性肝炎占７２－７ ％ ，进展至中期占１５ ％ ；而中期肝硬变逆转为慢性肝炎占２９ ％ ，转变晚期肝硬变占５８ ％ ，肝癌占１２－５ ％ ，两组间差异有极显著性（ Ｐ＜ ０－０１） ．结论 肝硬变分期对临床治疗及病理学机制研究有深远的意义．
Objective To study the clinicopathological significance of different stages of cirrhosis. Methods 456 biopsy specimens of liver cirrhosis were studied by HE, histochemistry, immunohistochemistry and electron microscopy. Results according to their histopathological manifestations can be divided into early, middle and advanced liver cirrhosis, which can be divided into A, B, C three pathological phenotypes. Suggesting that not only histological differences between the form, but the pseudolobule fibers with reticular, collagen, elastic fibers and FN, LN, Ⅳ Co also have differences (P <0-01), fiber with α SMA and Ⅷ F Ag Strong positive expression, indicating that vascular smooth muscle fibers predominance. Liver biopsy follow-up showed that early cirrhosis reversed to chronic hepatitis accounted for 72-7%, progress to the mid-term accounted for 15%; and intermediate liver cirrhosis reversed to chronic hepatitis accounted for 29%, 58% conversion of advanced cirrhosis, liver cancer accounted for 12-5%. There was significant difference between the two groups (P <0-01). Conclusions Staging of cirrhosis has far-reaching significance for clinical treatment and pathological mechanism.