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由于糖皮质激素可能直接作用于脱髓鞘轴突,对多发性硬化(MS)脱髓鞘区受损之传导性神经纤维有效,故作者用大剂量甲基强的松龙(1g/d×3天)静脉输入治疗8例MS 和2例急性视神经炎(ON),用诱发电位(EP)作前瞻性研究,结果如下:一、治疗前后之平均EP 值,除2例外均相同,但个体间有差异。二、视诱发电位(VEP):13只受检眼治疗前后的潜伏时延迟是相等的,但波幅均有增加(仍未达到正常),1只受检眼治疗前未见VEP,治疗后则出现,但有延迟。三、脑干听诱发电位(BAEP)2例呈双侧潜伏时延迟,1例有脑干损害征者未引出BAEP,这3例治疗后潜伏时均无改变。四、体感诱发电位(SEP):刺激正中神经见治
Since glucocorticoids may act directly on demyelinated axons and are effective on impaired conductive nerve fibers in demyelinating areas of multiple sclerosis (MS), the authors used high doses of methylprednisolone (1 g / d x 3 days) intravenous infusion of 8 cases of MS and 2 cases of acute optic neuritis (ON), the use of evoked potentials (EP) for prospective study, the results are as follows: First, the average EP before and after treatment, except for 2 cases were the same, but individuals There are differences between. Second, the apparent evoked potential (VEP): The latency of the 13 subjects before and after treatment was equal, but the amplitude was increased (still not up to normal), one subject did not see the pre-treatment VEP, after treatment Appears, but delayed. Three, brainstem auditory evoked potentials (BAEP) 2 cases were delayed bilateral latency, 1 case of brainstem lesion did not lead to BAEP, these 3 cases of latent changes after treatment were not changed. Fourth, somatosensory evoked potentials (SEP): to stimulate the median nerve see governance