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吡哌酸与已发展起来的第三代喹诺酮类抗菌药物因抗菌谱广,抗菌力强,使用安全,副作用小等优点,被认为是有广阔发展前途的药物。但据国外报道此类药物可引起儿童颅内压增高,尚可被幼小动物发育的软骨组织吸收而引起负重关节软骨受损。我科发现二例,现报告如下。例1 男,6个月。因呕吐、腹泻,咳嗽1周入院,不伴发热。查体一般情况尚好,除双肺听诊
Pipemidic acid and the third generation of quinolone antibacterials that have been developed have been considered as promising drugs due to their wide antibacterial spectrum, strong antimicrobial activity, safe use and small side effects. However, according to foreign reports of such drugs can cause increased intracranial pressure in children, can still be absorbed by the cartilage tissue of young animals and cause weight-bearing articular cartilage damage. Our department found two cases, the report is as follows. Example 1 male, 6 months. Due to vomiting, diarrhea, coughing for 1 week, without fever. Physical examination is generally good, except for lung auscultation