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目的对海洋真菌Nigrospora sphaerica中的化学成分进行研究。方法采用硅胶柱色谱、凝胶以及HPLC等方法进行分离纯化,根据理化性质和光谱数据进行结构鉴定。结果分离得到了8个化合物,分别鉴定为柄曲霉素(sterigmatocystin,1)、4-苄基-3-苯基-5氢呋喃酮(4-benzyl-3-phenyl-5H-furan-2-one,2)、异黄光素[7,8-dimethyl,benzo(g)pteridine-2,4(1H,3H)-dione,3]、5,8二羟基-7甲氧基黄酮(5,8-dihydroxy-7-methoxy-2-phenyl,4H-1-benzopyran-4-one,4)、1(2H)-3,4-二氢-4,8二羟基萘[3,4-dihydro-4,8-dihydroxy,1(2H)-naphthalenone,5]、3,5双去氧-5-苯基戊糖酸γ内酯(3,5-dideoxy-5-phenyl-,γ-lactone,pentonic acid,6)、4-羟基苯乙醇乙酯(4-hydroxyphe-nylethyl acetate,7)、1,4-二氧-2,5-二酮-3,6-二苯甲基聚酯[3,6-bis(phenylmethyl)-1,4-dioxane-2,5-dione,8]。结论真菌Nigrospora sphaerica为首次从海洋中分离得到,化合物1-8为首次从该菌中分离得到。
Objective To study the chemical constituents of marine fungus Nigrospora sphaerica. Methods The compounds were isolated and purified by silica gel column chromatography, gel and HPLC. The structures were elucidated on the basis of physico-chemical properties and spectral data. Results Eight compounds were isolated and identified as sterigmatocystin (1), 4-benzyl-3-phenyl-5H-furan-2- one, 2), isophorone [7,8-dimethyl, benzo (g) pteridine-2,4 (1H, 3H) -dione, 3], 5,8 dihydroxy-7methoxyflavone (5,8- dihydroxy-7-methoxy-2-phenyl, 4H-1-benzopyran-4-one, 8-dihydroxy, 1 (2H) -naphthalenone, 5], 3,5-dideoxy-5-phenyl- 6), 4-hydroxyphe-nylethyl acetate (7), 1,4-dioxa-2,5-dione-3,6-diphenylmethanepolyester [3,6- bis (phenylmethyl) -1,4-dioxane-2,5-dione, 8]. Conclusion The fungus Nigrospora sphaerica was isolated from the sea for the first time. Compounds 1-8 were isolated from this strain for the first time.