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背景:随着2型糖尿病患病率的上升,人们应重视其心血管并发症的早期干预,以降低其并发症的发病率。目的:观察2型糖尿病合并冠心病危险因素及冠状动脉造影情况。设计:以患者为研究对象,横断面的观察对比研究。单位:一所市级医院的内科病房。对象:实验于1998-05/2003-05在哈尔滨市第一医院内分泌科完成。纳入标准:符合1997年ADA确定的糖尿病诊断标准及1979年WHO制定的《缺血性心脏病的命名和诊断标准》的大于30岁的2型糖尿病合并冠心病患者;排除标准:患有严重心、肝、肾疾病及严重的感染,风湿性心脏病、肺源性心脏病者。98例住院患者符合上述纳入标准,设为糖尿病组,男56例,女42例,年龄为35～70岁。对照组为同期住院的非糖尿病冠心病患者85例,男53例,女32例,年龄为40～75岁。方法:观察血糖(葡萄糖氧化酶法)、空腹胰岛素和C肽(放免法)、糖化血红蛋白(亲和层析微柱法)血清三酰甘油、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇(全自动生化仪)及应用JUDKINS方法行选择性左右冠状动脉造影。主要观察指标:①2组冠状动脉造影结果比较;②糖尿病病程与冠状动脉病变支数关系的比较。结果:2组冠状动脉造影结果比较,糖尿病组的左主干病变、回旋支病变者与对照组相比,差异无显著性意义(P>0.05);而前降支和右冠状?
BACKGROUND: As the prevalence of type 2 diabetes increases, one should pay attention to its early intervention in cardiovascular complications to reduce the incidence of its complications. Objective: To observe the risk factors of type 2 diabetes mellitus complicated with coronary heart disease and coronary angiography. Design: The patient as the research object, cross-sectional observation of comparative study. Unit: a municipal hospital medical ward. PARTICIPANTS: The experiment was performed in the Department of Endocrinology, the First Hospital of Harbin from May 1998 to May 2003. Inclusion criteria: patients with type 2 diabetes and coronary heart disease more than 30 years of age who were diagnosed with Diabetes mellitus confirmed by ADA in 1997 and the WHO Nomenclature and Diagnostic Criteria for Ischemic Heart Disease, established in 1979; Exclusion Criteria: Patients with severe heart , Liver, kidney disease and severe infections, rheumatic heart disease, pulmonary heart disease. 98 cases of hospitalized patients meet the above criteria, set as diabetes group, 56 males and 42 females, aged 35 to 70 years. The control group was hospitalized in the same period 85 cases of non-diabetic patients with coronary heart disease, 53 males and 32 females, aged 40 to 75 years. Methods: The levels of serum triglyceride, total cholesterol, high density lipoprotein cholesterol, low density lipoprotein (LDL) and total cholesterol (LDL) were measured by glucose oxidase method, fasting insulin and C peptide Cholesterol (automatic biochemical analyzer) and the application of JUDKINS method of selective left and right coronary angiography. MAIN OUTCOME MEASURES: ① Comparison of results of coronary angiography in 2 groups; ② Comparison of the course of diabetes and the number of coronary lesions. Results: Compared with the control group, there was no significant difference between the two groups (P> 0.05); while the left anterior descending artery and the right coronary artery