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胃神经内分泌癌(NEC)是一种高度恶性肿瘤。然而,因其罕见有关其临床病理学特征的资料较少。为此,作者分析了51例胃NEC的形态学、免疫组织化学特点及其预后。组织学上,其中40例为大细胞型,11例为小细胞型;大多数肿瘤为实型生长(94%),部分肿瘤为小梁型(16%)、硬化型(10%)和小管型(6%)。36例(71%)肿瘤伴有腺癌成分和/或间变,其中26例(51%)伴有黏膜内腺癌或间变。免疫组化显示,48例(94%)、44例(86%)及24例(47%)肿瘤弥漫性表达突触素、嗜铬粒蛋
Gastric neuroendocrine carcinoma (NEC) is a highly malignant tumor. However, because of its rare information on its clinical and pathological features less. To this end, the author analyzed 51 cases of gastric NEC morphology, immunohistochemical features and prognosis. Histologically, 40 cases were large cell type and 11 cases were small cell type. Most of the tumors were real growth (94%), some of them were trabecular (16%), sclerosing (10%) and tubule Type (6%). Thirty-six patients (71%) had adenocarcinoma and / or metachronous changes, of which 26 (51%) had adenocarcinoma or anaplastic lesions. Immunohistochemistry showed that diffuse expression of synaptophysin, chromophobe granulocytes in 48 (94%), 44 (86%) and 24 (47%) tumors