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目的：初步观察静脉溶栓治疗急性脑梗死的效果和安全性。方法：尿激酶（UK）静脉溶栓治疗6小时内急性颈动脉系统脑梗死开放性临床病例研究。结果：选择中重度瘫痪，溶栓治疗前脑CT无早期梗死大块低密度改变患者38例。静脉滴注UK至发病时间4．4±1．1h。UK剂量141±29万UI。溶栓治疗后2小时出现戏剧性神经功能改善7例，24小时主要神经功能缺损改善（欧洲脑卒中评分较溶栓前＞10分）23例。表现血管再闭塞4例。合并症状性脑出血3例，出血性梗死4例。随访3月，基本痊愈14例；轻微神经功能损害8例；中重度神经系统后遗症11例；死亡5例，其中1例死于脑出血。结论：UK静脉溶栓治疗急性脑梗死是安全、有效的。
Objective: To observe the efficacy and safety of intravenous thrombolysis in the treatment of acute cerebral infarction. Methods: The clinical study of open carotid system cerebral infarction within 6 hours after urokinase (UK) intravenous thrombolysis was performed. Results: Thirty-eight patients with moderate or severe paralysis and thrombolysis were selected in the study. Intravenous drip UK to the onset of time 4.4 ± 1.1h. UK dose 141 + 290,000 UI. There were 7 cases of dramatic neurological improvement 2 hours after thrombolysis and 23 cases of improvement of major neurological deficits at 24 hours (European Stroke Score> 10 before thrombolysis). Renal vascular occlusion in 4 cases. Symptomatic intracerebral hemorrhage in 3 cases, 4 cases of hemorrhagic infarction. Follow-up in March, 14 cases were basically cured; 8 cases of mild neurological dysfunction; 11 cases of moderate and severe neurological sequelae; 5 cases died, 1 case died of cerebral hemorrhage. Conclusion: UK intravenous thrombolytic therapy for acute cerebral infarction is safe and effective.