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目的:分析和研究肺表面活性物质(PS)治疗足月新生儿急性呼吸窘迫综合征(ARDS)有效性。方法:选取2013年01月-2015年01月河池市人民医院足月新生儿急性呼吸窘迫综合征患儿50例,按投币法随机分为联合治疗组25例与通气治疗组25例。所有患儿采用呼吸机治疗,而联合治疗组患儿在此基础上给予肺表面活性物质治疗。将两组患儿治疗24 h后血气指标检测值、患儿呼吸机使用时间、重症监护病房(ICU)治疗时间、呼吸机相关并发症发生率及患儿死亡率进行对比。结果:1两组患儿治疗后呼吸机参数最高平均动脉压(MAP)水平和吸入高浓度氧(Fi O2≥50%)持续时间相比较可见联合治疗组患儿明显优于通气治疗组患儿,组间比较,差异具有统计学意义(P<0.05);2联合治疗组患儿呼吸机使用时间、新生儿重症监护病房(NICU)治疗时间明显短于通气治疗组患儿,差异具有统计学意义(P<0.05);3两组患儿并发气胸、肺出血、呼吸机相关肺炎发生率,临床死亡率相比较发现,联合治疗组均明显低于通气治疗组,两组之间差异具有统计学意义(P<0.05)。结论:在常规机械通气治疗基础上,给予足月新生儿急性呼吸窘迫综合征患儿PS治疗,有利于缩短呼吸机使用时间、NICU病房治疗时间,且明显减少了呼吸机相关并发症发生率及患儿死亡率。
PURPOSE: To analyze and study the effectiveness of pulmonary surfactant (PS) in the treatment of full-term neonatal acute respiratory distress syndrome (ARDS). Methods: From January 2013 to January 2015, 50 children with full-term neonatal acute respiratory distress syndrome in Hechi People’s Hospital were randomly divided into 25 cases in combination therapy group and 25 in ventilation therapy group. All children were treated with ventilator, and children in the combination therapy group were given pulmonary surfactant treatment on this basis. After 24 hours of treatment, the two groups of children were compared for blood gas test, ventilator use time, intensive care unit (ICU) treatment time, ventilator-related complication rate and child mortality rate. Results: Compared with the duration of inhalation of high concentration oxygen (Fi O2≥50%), the mean arterial pressure (MAP) of ventilator parameters in two groups of children after treatment was significantly better than that in ventilator-treated children (P <0.05) .2 The duration of ventilator use and the neonatal intensive care unit (NICU) treatment time in the combined treatment group were significantly shorter than those in the ventilated treatment group, the difference was statistically significant (P <0.05) .3 Compared with the pneumoconiosis, pulmonary hemorrhage, ventilator-associated pneumonia and clinical mortality, the two groups of children were significantly lower than the ventilation treatment group, the difference was statistically significant Significance (P <0.05). CONCLUSION: PS treatment of full-term newborn infants with acute respiratory distress syndrome is beneficial to shorten the time of ventilator and NICU ward time, and significantly reduce the incidence of ventilator-related complications Child mortality.