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目的探讨PSA及其相关参数(F/T、PSAD)在前列腺癌骨转移中的预测作用;方法回顾我院2002年5月￣2005年3月收治的前列腺癌病例,对其中PSA及其相关参数资料完整的87例进行分析,分析这些指标参数与前列腺癌骨转移的相关性和对骨转移的诊断价值,并用ECT和MRI进行验证;结果按PSA50μg/L对前列腺癌患者进行分层,PSA及PSAD与前列腺癌骨转移成正相关(分别为r=0.45038,P<0.0028和r=0.64158,P<0.0001),而F/T则没有相关性。根据上述结果,再以PSA>50μg/L和PSAD>0.4为界分别用PSA、PSAD和PSAD联合PSA对前列腺癌骨转移进行诊断分析,结果发现PSAD+PSA联合诊断应用后,诊断的敏感度、阴性预测值明显提高,对诊断有明显帮助。结论PSAD+PSA联合应用诊断前列腺癌骨转移,是对传统ECT和MRI诊断前列腺癌骨转移的重要补充,对ECT和MRI所带来射线损害的降低和经济负担的减少有重要意义。
Objective To investigate the predictive value of PSA and its related parameters (F / T, PSAD) in bone metastasis of prostate cancer. Methods The clinical data of prostate cancer from May 2002 to March 2005 in our hospital were reviewed. The PSA and its related parameters The data of 87 cases were analyzed. The correlation between these parameters and the bone metastasis of prostate cancer and the diagnostic value of bone metastasis were analyzed. The results of ECT and MRI were validated. The results showed that PSA <10μg / L, 10-50μg / L and PSA > 50 μg / L stratified prostate cancer patients, PSA and PSAD were positively correlated with bone metastases of prostate cancer (r = 0.45038, P <0.0028 and r = 0.64158, respectively, P <0.0001), while F / T had no correlation . According to the above results, the PSA, PSAD and PSAD combined with PSA were respectively used to diagnose prostate cancer bone metastases by PSA> 50μg / L and PSAD> 0.4. The results showed that the diagnostic sensitivity, Negative predictive value was significantly improved, the diagnosis was significantly help. Conclusions The combination of PSAD + PSA for the diagnosis of prostate cancer bone metastasis is an important supplement to traditional ECT and MRI in the diagnosis of prostate cancer bone metastasis. It is of great significance to reduce the radiation damage and reduce the economic burden caused by ECT and MRI.