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阿魏硝胺（ＥＮＦ）在豚鼠离体工作心脏上仅增加冠脉流量，而对心功能则无明显影响。实验同时比较了ＥＮＦ及与其有着相同活性基团的钾通道开放剂尼可地尔（ＮＩＣ）对大鼠胸主动脉血管环的舒张作用。两药对新福林（５μｍｏｌ／Ｌ）诱导的血管环收缩呈剂量依赖性舒张，其效能基本一致。格列本脲（１μｍｏｌ／Ｌ）可明显阻断ＮＩＣ（１０￣（－５）μｍｏｌ／Ｌ）的舒血管作用。但不能阻断ＥＮＦ（１０￣（－５）μ±ｍｏｌ／Ｌ）的作用。ｃＧＭＰ合成阻断剂甲蓝可使两药的舒张作用均减弱。对于８０ｍｍｏｌ／ＬＫ￣＋诱导的血管环收缩，ＥＮＦ及ＮＩＣ分别舒张７２±８％，７２±８％（Ｐ＜０．０１）。结果提示，ＥＮＦ能改善冠脉循环及通过硝基化合物样作用舒张血管而无钾通道开放作用。
Ferulic nitramine (ENF) only increased coronary flow in isolated guinea pig hearts, but had no significant effect on cardiac function. At the same time, we compared the relaxation of ENF and nicorandil, a potassium channel opener with the same active groups, on the thoracic aorta in rats. The two drugs on the new Fulin (5μmol / L) -induced contraction of the vascular ring in a dose-dependent manner, its efficacy is basically the same. Glibenclamide (1 μmol / L) significantly blocked the vasorelaxing effect of NIC (10 ~ (-5) μmol / L). But failed to block the effect of ENF (10 ~ (-5) μ ± mol / L). cGMP synthetic blocker methylene blue can make both the relaxation effect are weakened. For 80mmol / L K ~ +-induced vasoconstriction, ENF and NIC were 72 ± 8% and 72 ± 8% (P <0.01), respectively. The results suggest that ENF improves coronary circulation and relaxes blood vessels through a nitro compound-like activity without potassium channel opening.