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CCK受体在急性胰腺炎发病中起重要作用,应用CCK受体拮抗剂能显著抑制胰腺分泌,减轻炎症程度,提高急性胰腺炎生存率。前列腺素能抑制多种外源性与内源性刺激引起的胰腺分泌,并能增加胰腺血流量及具有细胞保护作用。生长抑素及其衍生物不仅能直接或间接地抑制胃肠激素分泌,而且对胰腺实质细胞有直接保护和抑制磷脂酶A_2活性的作用。氧自由基清除剂、血小板活化因子拮抗剂对实验性急性胰腺炎也有显著疗效。
CCK receptor plays an important role in the pathogenesis of acute pancreatitis. CCK receptor antagonist can significantly inhibit pancreatic secretion, reduce the degree of inflammation and improve the survival rate of acute pancreatitis. Prostaglandin can inhibit a variety of exogenous and endogenous stimulation caused by pancreatic secretion, and can increase pancreatic blood flow and a cytoprotective effect. Somatostatin and its derivatives not only directly or indirectly inhibit gastrointestinal hormone secretion, but also have direct protection of pancreatic parenchyma cells and inhibit phospholipase A 2 activity. Oxygen free radical scavengers, platelet-activating factor antagonists also have a significant effect on experimental acute pancreatitis.