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目的:观察骨痹汤联合西药治疗骨质疏松症的临床疗效。方法:选取100例骨质疏松症患者随机分为治疗组和对照组各50例,治疗组用自拟的中药骨痹汤联合西药阿仑膦酸钠、钙尔奇D3进行治疗,对照组服用阿仑膦酸钠和钙尔奇D3进行治疗。2组疗程均为6月。观察患者治疗前后腰椎L2~4、股骨颈、Ward′s三角区的骨密度和疼痛改善情况。结果:治疗后对照组腰椎、股骨颈及Ward′s三角区的骨密度均较治疗前有升高趋势,但差异均无显著性意义(P>0.05);治疗后治疗组腰椎、股骨颈及Ward′s三角区的骨密度均较治疗前升高,并均高于对照组,差异有显著性或非常显著性意义(P<0.05,P<0.01)。疼痛缓解有效率对照组为52.0%,治疗组为72.0%,2组有效率比较,差异有显著性意义(P<0.05)。疾病疗效总有效率对照组为68.0%,治疗组为88.0%,2组总有效率比较,差异有显著性意义(P<0.05)。2组均无严重不良反应发生,且2组不良反应发生率比较,差异无显著性意义(P>0.05)。结论:中药骨痹汤联合阿仑膦酸钠和钙尔奇D3治疗骨质疏松症疗效显著,安全性好,值得临床推广。
Objective: To observe the clinical effect of Gubi Tang combined with western medicine in treating osteoporosis. Methods: One hundred cases of osteoporosis were randomly divided into treatment group and control group, 50 cases in each group. The treatment group was treated with the traditional Chinese medicine Gubi Tang combined with western medicine alendronate and calcium chloride D3, and the control group Alendronate and Calcium D3 are treated. 2 groups of treatment are June. To observe the patients before and after treatment of lumbar spine L2 ~ 4, the femoral neck, Ward’s triangle of bone mineral density and pain improvement. Results: After treatment, the BMD of lumbar spine, femoral neck and Ward’s triangle in control group increased compared with that before treatment, but there was no significant difference (P> 0.05). The lumbar spine, femoral neck, The BMD of Ward’s triangle area was significantly higher than that of the control group before treatment, and the difference was significant or very significant (P <0.05, P <0.01). The effective rate of pain relief was 52.0% in the control group and 72.0% in the treatment group, and the difference was significant between the two groups (P <0.05). The total effective rate of the disease was 68.0% in the control group and 88.0% in the treatment group, and the total effective rate in the two groups was significantly different (P <0.05). No serious adverse reactions occurred in both groups, and there was no significant difference between the two groups in the incidence of adverse reactions (P> 0.05). Conclusion: The traditional Chinese medicine Gubi Tang combined alendronate and Calcium D3 treatment of osteoporosis significant effect, good safety, worthy of clinical promotion.