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免疫系统是尚未完全了解的复杂的网络系统,需要新工具以揭示这一网络的最小组分间的关系。FK506和雷怕霉素在临床上可能用作选择性免疫抑制剂,因而受到重视。最近两年发现两种具有免疫抑制活性的大环内酯物——FK506和雷怕霉素在延长动物同种移植器官的存活和阻止自身免疫病发作方面极为有效。两种药物都抑制T细胞增殖,但作用于T细胞活化的不同阶段,与环孢菌素A类似,FK506在早期抵消促有丝分裂或抗原刺激,抑制细胞从静止的G_0期进入细胞周期的G_1期,而雷怕霉素干扰与DNA合成关系更为密切的过程,在G_1后期、S期前抑制细胞分裂。两者很可能具有不依赖于DNA复制激活
The immune system is a complex network system that is not yet fully understood, and new tools are needed to uncover the relationships between the smallest components of the network. FK506 and rapamycin may be clinically used as selective immunosuppressive agents and are therefore valued. In the recent two years, two macrolide compounds with immunosuppressive activity, FK506 and rapamycin, were found to be extremely effective in prolonging the survival of allografts in animals and preventing the onset of autoimmune diseases. Both drugs inhibit T cell proliferation but act on different stages of T cell activation similar to cyclosporin A and FK506 counteracts mitogenic or antigenic stimuli at early stages and inhibits cell entry from the stationary G 0 phase into the G 1 phase of the cell cycle , Whereas rapamycin interfered with the process of DNA synthesis more closely, inhibiting cell division before G and S phase. Both are likely to be independent of DNA replication activation