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目的通过1255对不良孕产史夫妇外周血染色体核型分析,探讨不良孕产史与染色体异常核型的关系。方法收集1255对不良孕产史夫妇相应的临床资料,抽取患者外周血,采用外周血淋巴细胞培养,常规法制备染色体标本,G显带,镜下核型分析。结果 1255对不良孕产史夫妇中,共检出异常核型175例,占7.14%。异常核型中染色体多态性为91例,占52%;平衡易位为55例,占31.42%;倒位9例,占5.14%;性染色体异常20例,占11.42%。结论染色体异常是导致不良孕产史的重要原因。对不良孕产史夫妇进行染色体核型分析可进行病因诊断及指导优生提供重要依据。
Objective To analyze the karyotypes of chromosomes in peripheral blood of 1255 couples with unhealthy maternity and to explore the relationship between the history of unhealthy maternity and the karyotypes of chromosomal abnormalities. Methods The clinical data of 1255 couples with adverse pregnancy history were collected. Peripheral blood was collected from patients and cultured in peripheral blood lymphocytes. Chromosome specimens were prepared by conventional method. G - banding and microscopic karyotype analyzes were performed. Results Among 1255 couples with adverse pregnancy history, 175 cases were abnormal karyotypes, accounting for 7.14%. Abnormal karyotype chromosomal polymorphism in 91 cases, accounting for 52%; balance of translocation was 55 cases, accounting for 31.42%; inverted in 9 cases, accounting for 5.14%; 20 cases of chromosomal abnormalities, accounting for 11.42%. Conclusion Chromosomal abnormalities are the important causes of adverse pregnancy history. Chronic karyotype analysis of maternal history of poor couples can provide etiological diagnosis and guide eugenic important basis.