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目的：探究伊曲康唑联合2%酮康唑乳膏治疗股癣的临床疗效。方法：选取94例足癣患者，随机分为治疗组(口服伊曲康唑胶囊200mg 每天1次，联合外用2%酮康唑乳膏每天2次)；对照组(单纯外用2%酮康唑乳膏每天2次)，用药疗程均为4周。观察两组患者用药后2周及4周的临床疗效和真菌学疗效及不良反应。结果：用药后2周治疗组和对照组总有效率分别为25.5%、17.0%，真菌清除率分别为25.5%、17.0%，两组比较差异无统计学意义(P>0.05)；用药后4周治疗组和对照组总有效率分别为61.7%、40.4%，真菌清除率分别为68.1%、44.7%，两组比较差异有统计学意义(P<0.05)。两组患者用药后均无严重不良反应发生。结论：口服伊曲康唑胶囊联合外用2%酮康唑乳膏比单纯外用2%酮康唑乳膏治疗股癣近期临床疗效好，且副作用少，是临床治疗股癣疗效较好的方法之一。“,”Objective:Objective:To observe the ef icacy of ora lItraconazole Capsules combined with external use 2% ketoconazole cream treating tinea cruris. Methods:94 patients with tinea cruris ,were randomly divided into treatment group and control group . Treatment group oral Itraconazole Capsules combined with externaluse 2% ketoconazole cream treating 47patients with tinea cruris ,the total course of 4 weeks . Control group external use 2% ketoconazole cream treating 47 patients with tinea cruris ,the total course of 4 weeks . Observe two groups of patients with drug use 2 weeks and 4 weeks of clinical curative ef ect and mycology curative ef ect and adverse reactions . Results:Two groups of patients with druguse 2 weeks the ef ective rate were25. 5%and 17. 0 % respectively ,the fung use radication rate were 25. 5% and17. 0% respectively . There was no statistical y significant dif erence comparing the two groups(P﹥0. 05) . Two groups of patients with drug use 4 weeks the ef ective rate were 61. 7% and 40. 4% respectively ,the fung use radication rate were 68. 1% and 44. 7% respectively . Comparative dif erences between the two groups have statistical significance(P< 0. 05). Two groups of patients with no serious adverse reaction after taking this medicine. Conclusion:Oral Itraconazole Capsules combined with exter-nal use 2%ketoconazole cream in the treatment of tinea cruris clinical curative ef ect is good ,Side ef ects are less .