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作者采用噻唑蓝(MTT)法对36例恶性肿瘤合并恶性腹水患者腹水肿瘤细胞进行化疗药物敏感性测定,并根据测定结果进行临床化疗,结果表明,腹水可用于药物敏感性测定,可评价率为75%;腹水标本可替代实体瘤标本作体外化疗药物敏感试验;不同肿瘤患者个体之间药物敏感性不同;药敏结果用于个体化治疗效果良好。
The authors used thiazolyl blue (MTT) method for chemotherapeutic drug susceptibility testing of ascites tumor cells in 36 malignant tumor patients with malignant ascites, and according to the results of clinical chemotherapy, the results showed that ascites can be used for drug sensitivity determination, can be evaluated rate 75%; ascites specimens can be used as a substitute for solid tumor specimens for in vitro chemotherapy drug sensitivity testing; patients with different tumors have different drug sensitivities; susceptibility results are good for individualized therapy.