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目的 :观察中西医结合治疗慢性胰腺炎的临床疗效。方法 :慢性胰腺炎患者共80例,采用随机数字表法随机分为2组各40例。对照组进行西医基础治疗以及抑酸药、促进胃动力药、止痛药等对症治疗药物,并进行饮食控制;观察组在对照组治疗基础上加用柴胡疏肝散治疗,每天1剂,分早、晚2次服用,连续治疗4周。治疗前后对2组患者临床表现、体征进行观察,比较2组临床疗效;治疗前后对患者血清中脂肪酶、对氧磷酶、淀粉酶活性进行检测。结果:2组临床疗效愈显率、总有效率比较,差异均有统计学意义(P<0.05);治疗4周后,观察组患者腹痛、腹胀、黄疸、消化吸收不良及脂肪泻等临床症状评分均低于对照组,差异有统计学意义(P<0.05);观察组患者血清脂肪酶和淀粉酶活性低于对照组,对氧磷酶1活性高于对照组,差异有统计学意义(P<0.05)。结论:柴胡疏肝散在CP治疗中具有积极作用,可能与柴胡疏肝散抗氧化应激和抑制炎症反应的功效有关。
Objective: To observe the clinical efficacy of integrated traditional Chinese and western medicine in the treatment of chronic pancreatitis. Methods: A total of 80 patients with chronic pancreatitis were randomly divided into two groups of 40 cases using random number table. The control group was treated with Western medicine and antacids, promoting gastric motility drugs, painkillers and other symptomatic treatment drugs, and diet control; observation group in the control group based on the treatment with Chaihu Shugan San, a day, Take morning and evening 2 times, continuous treatment for 4 weeks. The clinical manifestations and signs of the two groups were observed before and after treatment, and the clinical efficacy was compared between the two groups. The levels of lipase, paraoxonase and amylase in the serum of the patients before and after treatment were measured. Results: After 2 weeks of treatment, the clinical symptoms such as abdominal pain, abdominal distension, jaundice, dyspepsia and steatorrhea were observed in the observation group after 4 weeks of treatment (P <0.05). The serum lipase and amylase activities in the observation group were lower than those in the control group, and the activity of paraoxonase 1 was higher than that in the control group (P <0.05). The difference was statistically significant (P < P <0.05). Conclusion: Chaihu Shugan San has a positive effect on the treatment of CP, which may be related to the effect of Chaihu Shugan San in inhibiting oxidative stress and inhibiting inflammatory reaction.